HitPredict

Interactor 1: IFNB (P01574)
Interferon beta (IFN-beta) (Fibroblast interferon)
Gene: IFNB1

Interactor 2: IRF3 (Q14653)
Interferon regulatory factor 3 (IRF-3)
Gene: IRF3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.756

Property	Details
Experiments	10848607, 15664995, 15699120, 19152337, 18781139, 17652396, 17560375, 16984921, 17035306, 16014923, 16537619, 19349300, 20581830
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, x-ray crystallography, electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051607 - defense response to virus GO:0060337 - type I interferon-mediated signaling pathway GO:0071360 - cellular response to exogenous dsRNA and 1 others more... GO:0098586 - cellular response to virus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 187 Hs			1 427
+	Hs
		352755 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Hs
		352770 IFNA2_HUMAN (23-187): 2.08e-72: 218: 33.73		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Hs
		352788 IFNA7_HUMAN (9-186): 3.79e-72: 218: 32.62		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Hs
		352844 IFN14_HUMAN (10-186): 1.71e-71: 216: 32.60		IRF3_HUMAN (1-427): 0: 604: 100.00
+	Hs
		352878 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF8_HUMAN (7-387): 6.94e-148: 428: 27.32
+	Hs
		352882 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		352753 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Hs
		352842 IFN14_HUMAN (10-186): 1.71e-71: 216: 32.60		IRF5_HUMAN (2-413): 1.48e-143: 420: 29.78
+	Mm
		352888 IFNB_MOUSE (1-187): 4.49e-60: 186: 49.20		IRF8_MOUSE (7-393): 8.11e-150: 433: 28.04
+	Mm
		352891 IFNB_MOUSE (1-187): 4.49e-60: 186: 49.20		IRF5_MOUSE (2-413): 1.06e-144: 423: 29.81
+	Hs
		352885 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352758 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352775 IFNA2_HUMAN (23-187): 2.08e-72: 218: 33.73		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352791 IFNA7_HUMAN (9-186): 3.79e-72: 218: 32.62		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352848 IFN14_HUMAN (10-186): 1.71e-71: 216: 32.60		IRF7_HUMAN (4-383): 1.71e-105: 323: 26.03
+	Hs
		352861 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		352862 IFNB_HUMAN (1-187): 1.53e-76: 228: 100.00		IRF2_HUMAN (1-116): 1.85e-48: 170: 33.90
+	Hs
		352745 IFNA1_HUMAN (10-186): 1.82e-74: 223: 31.49		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		352766 IFNA2_HUMAN (23-187): 2.08e-72: 218: 33.73		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23
+	Hs
		352837 IFN14_HUMAN (10-186): 1.71e-71: 216: 32.60		IRF1_HUMAN (1-189): 8.3e-49: 170: 24.23