HitPredict

Interactor 1: LV208 (P01709)
Immunoglobulin lambda variable 2-8 (Ig lambda chain V-II region BO) (Ig lambda chain V-II region MGC)
Gene: IGLV2-8

Interactor 2: IGHG1 (P01857)
Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
Gene: IGHG1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	8483943
Identification Methods	x-ray crystallography
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1-set~V-set
Common GO terms	GO:0002250 - adaptive immune response GO:0003823 - antigen binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 118 Hs			1 399
+	Hs
		353698 Q8N355_HUMAN (1-118): 1.33e-47: 153: 53.39		IGHG1_HUMAN (1-399): 4.54e-108: 325: 100.00
+	Hs
		353350 HV307_HUMAN (1-111): 4.11e-44: 141: 25.42		IGHG1_HUMAN (1-399): 4.54e-108: 325: 100.00
+	Hs
		353347 HV323_HUMAN (1-111): 2.53e-43: 139: 27.97		IGHG1_HUMAN (1-399): 4.54e-108: 325: 100.00
+	Hs
		353203 LV147_HUMAN (1-115): 6.76e-42: 135: 68.70		IGHG1_HUMAN (1-399): 4.54e-108: 325: 100.00
+	Mm
		353201 KV3A8_MOUSE (20-116): 3.79e-41: 133: 44.44		GCAM_MOUSE (2-399): 2.18e-94: 290: 66.92
+	Mm
		353195 KV2A7_MOUSE (20-111): 1.67e-40: 131: 46.32		IGG2B_MOUSE (2-399): 1.27e-94: 291: 63.95
+	Mm
		353194 KV2A7_MOUSE (20-111): 1.67e-40: 131: 46.32		GCAM_MOUSE (2-399): 2.18e-94: 290: 66.92
+	Mm
		353202 KV3AD_MOUSE (20-116): 5.82e-42: 135: 44.44		IGHG1_MOUSE (1-329): 1.44e-67: 218: 60.79
+	Mm
		353221 LV1B_MOUSE (1-116): 1.26e-41: 135: 40.52		IGHG1_MOUSE (1-329): 1.44e-67: 218: 60.79
+	Hs
		353181 KVD40_HUMAN (4-116): 5.26e-45: 143: 41.88		IGHA1_HUMAN (1-374): 5.12e-63: 209: 29.85
+	Mm
		353224 LV1E_MOUSE (1-116): 4.5e-41: 133: 38.79		IGHG1_MOUSE (1-329): 1.44e-67: 218: 60.79
+	Mm
		353196 KV2A7_MOUSE (20-111): 1.67e-40: 131: 46.32		IGHG1_MOUSE (1-329): 1.44e-67: 218: 60.79
+	Hs
		353189 KV320_HUMAN (15-116): 2.06e-42: 136: 46.60		IGHA1_HUMAN (1-374): 5.12e-63: 209: 29.85
+	Hs
		353205 LV147_HUMAN (1-115): 6.76e-42: 135: 68.70		IGHA1_HUMAN (1-374): 5.12e-63: 209: 29.85
+	Hs
		353180 KVD40_HUMAN (4-116): 5.26e-45: 143: 41.88		IGHM_HUMAN (1-358): 2.62e-22: 100: 19.90
+	Hs
		353204 LV147_HUMAN (1-115): 6.76e-42: 135: 68.70		IGHM_HUMAN (1-358): 2.62e-22: 100: 19.90
+	Hs
		353349 HV333_HUMAN (1-111): 7.95e-45: 143: 27.12		IGLC1_HUMAN (2-103): 3.03e-11: 61.7: 31.43
+	Hs
		353209 LV208_HUMAN (1-118): 6.94e-44: 140: 100.00		IGLC1_HUMAN (2-103): 3.03e-11: 61.7: 31.43
+	Mm
		526804 VPREB_MOUSE (1-117): 2.24e-40: 132: 38.21		IGLL1_MOUSE (2-103): 6.99e-12: 66.3: 30.48