HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.62	0.90	0.749

Property	Details
Experiments	15047060, 9168119
Identification Methods	affinity chromatography technology, x-ray crystallography, protein cross-linking with a bifunctional reagent
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C2-set~C2-set, C2-set~CD4-extracel, C2-set~ig, ig~ig
Common GO terms	GO:0001618 - virus receptor activity GO:0001934 - positive regulation of protein phosphorylation GO:0002250 - adaptive immune response GO:0004888 - transmembrane signaling receptor activity GO:0005201 - extracellular matrix structural constituent and 50 others more... GO:0005769 - early endosome GO:0005788 - endoplasmic reticulum lumen GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0006955 - immune response GO:0007165 - signal transduction GO:0007166 - cell surface receptor signaling pathway GO:0007167 - enzyme-linked receptor protein signaling pathway GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0008270 - zinc ion binding GO:0008289 - lipid binding GO:0009897 - external side of plasma membrane GO:0015026 - coreceptor activity GO:0019722 - calcium-mediated signaling GO:0019899 - enzyme binding GO:0019901 - protein kinase binding GO:0023026 - MHC class II protein complex binding GO:0030217 - T cell differentiation GO:0030225 - macrophage differentiation GO:0030669 - clathrin-coated endocytic vesicle membrane GO:0032507 - maintenance of protein location in cell GO:0032743 - positive regulation of interleukin-2 production GO:0033674 - positive regulation of kinase activity GO:0035397 - helper T cell enhancement of adaptive immune response GO:0035723 - interleukin-15-mediated signaling pathway GO:0038023 - signaling receptor activity GO:0042011 - interleukin-16 binding GO:0042012 - interleukin-16 receptor activity GO:0042101 - T cell receptor complex GO:0042110 - T cell activation GO:0042289 - MHC class II protein binding GO:0042803 - protein homodimerization activity GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043410 - positive regulation of MAPK cascade GO:0045058 - T cell selection GO:0045121 - membrane raft GO:0045657 - positive regulation of monocyte differentiation GO:0045860 - positive regulation of protein kinase activity GO:0045893 - positive regulation of DNA-templated transcription GO:0046598 - positive regulation of viral entry into host cell GO:0050731 - positive regulation of peptidyl-tyrosine phosphorylation GO:0050829 - defense response to Gram-negative bacterium GO:0050850 - positive regulation of calcium-mediated signaling GO:0050863 - regulation of T cell activation GO:0050870 - positive regulation of T cell activation GO:0051924 - regulation of calcium ion transport GO:0070374 - positive regulation of ERK1 and ERK2 cascade GO:0097011 - cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:1990782 - protein tyrosine kinase binding
Homologous interactions	0