HitPredict

Interactor 1: CD4 (P01730)
T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
Gene: CD4

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 0.60 0.744

The method score is based on:

Property Details
Experiments 36736316, 17653867, 12007789, 11854499, 15047060, 16888650, 17005671, 8246987
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0019901 - protein kinase binding
GO:0030217 - T cell differentiation
GO:0045121 - membrane raft
and 1 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 458
Hs

1 509
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024