HitPredict

Interactor 1: CD4 (P01730)
T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
Gene: CD4

Interactor 2: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.57 0.60 0.588

The method score is based on:

Property Details
Experiments 10816381, 15660419
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001618 - virus receptor activity
GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:0007166 - cell surface receptor signaling pathway
GO:0009897 - external side of plasma membrane
and 2 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 458
Hs

1 352
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024