HitPredict

Interactor 1: CD8A (P01732)
T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
Gene: CD8A

Interactor 2: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	9177355, 10809759
Identification Methods	x-ray crystallography, pull down
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	C1-set~V-set, MHC_I~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0006955 - immune response GO:0009897 - external side of plasma membrane GO:0050852 - T cell receptor signaling pathway
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 235 Hs			1 365
+	Hs
		353321 CD8A_HUMAN (1-235): 2.86e-147: 411: 100.00		HLAB_HUMAN (1-362): 3.05e-157: 447: 85.64
+	Hs
		353329 CD8A_HUMAN (1-235): 2.86e-147: 411: 100.00		HLAG_HUMAN (1-338): 2.35e-151: 431: 82.84
+	Hs
		353326 CD8A_HUMAN (1-235): 2.86e-147: 411: 100.00		HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27