HitPredict

Interactor 1: HV323 (P01764)
Immunoglobulin heavy variable 3-23 (Ig heavy chain V-III region LAY) (Ig heavy chain V-III region POM) (Ig heavy chain V-III region TEI) (Ig heavy chain V-III region TIL) (Ig heavy chain V-III region TUR) (Ig heavy chain V-III region VH26) (Ig heavy chain V-III region WAS) (Ig heavy chain V-III region ZAP)
Gene: IGHV3-23

Interactor 2: IGHG1 (P01857)
Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)
Gene: IGHG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	15174051
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	C1-set~V-set
Common GO terms	GO:0003823 - antigen binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0070062 - extracellular exosome and 1 others more... GO:0072562 - blood microparticle
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 117 Hs			1 399
+	Hs
		353350 HV307_HUMAN (1-117): 3.8e-55: 169: 86.33		IGHG1_HUMAN (1-399): 4.54e-108: 325: 100.00
+	Hs
		353698 Q8N355_HUMAN (1-116): 1.06e-37: 128: 26.72		IGHG1_HUMAN (1-399): 4.54e-108: 325: 100.00
+	Hs
		353750 HV431_HUMAN (1-117): 9.79e-43: 137: 48.74		IGHG2_HUMAN (1-399): 3.98e-103: 312: 90.48
+	Hs
		353208 LV208_HUMAN (1-116): 1.41e-34: 117: 29.06		IGHG1_HUMAN (1-399): 4.54e-108: 325: 100.00
+	Hs
		353871 HV431_HUMAN (1-117): 9.79e-43: 137: 48.74		IGHG4_HUMAN (1-399): 5.43e-99: 301: 91.98
+	Hs
		353837 HV431_HUMAN (1-117): 9.79e-43: 137: 48.74		IGHG3_HUMAN (1-399): 7.71e-97: 298: 83.86
+	Hs
		353203 LV147_HUMAN (1-116): 5.79e-30: 105: 25.86		IGHG1_HUMAN (1-399): 4.54e-108: 325: 100.00
+	Hs
		354141 Q9UL92_HUMAN (20-117): 5.84e-41: 133: 62.25		IGHA1_HUMAN (1-374): 5.12e-63: 209: 29.85
+	Hs
		353181 KVD40_HUMAN (6-117): 4.63e-37: 123: 23.93		IGHA1_HUMAN (1-374): 5.12e-63: 209: 29.85
+	Hs
		353205 LV147_HUMAN (1-116): 5.79e-30: 105: 25.86		IGHA1_HUMAN (1-374): 5.12e-63: 209: 29.85
+	Hs
		353349 HV333_HUMAN (1-117): 5.83e-57: 173: 85.47		IGLC1_HUMAN (2-103): 3.03e-11: 61.7: 31.43
+	Hs
		353180 KVD40_HUMAN (6-117): 4.63e-37: 123: 23.93		IGHM_HUMAN (1-358): 2.62e-22: 100: 19.90
+	Hs
		353204 LV147_HUMAN (1-116): 5.79e-30: 105: 25.86		IGHM_HUMAN (1-358): 2.62e-22: 100: 19.90
+	Mm
		526804 VPREB_MOUSE (1-116): 1.46e-40: 133: 29.06		IGLL1_MOUSE (2-103): 6.99e-12: 66.3: 30.48
+	Hs
		353209 LV208_HUMAN (1-116): 1.41e-34: 117: 29.06		IGLC1_HUMAN (2-103): 3.03e-11: 61.7: 31.43