HitPredict

Interactor 1: IGKC (P01834)
Immunoglobulin kappa constant (Ig kappa chain C region) (Ig kappa chain C region AG) (Ig kappa chain C region CUM) (Ig kappa chain C region EU) (Ig kappa chain C region OU) (Ig kappa chain C region ROY) (Ig kappa chain C region TI)
Gene: IGKC

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	24725412
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	C1-set~LRR_8
Common GO terms	GO:0005615 - extracellular space GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 107 Hs			1 2527
+	Hs
		1130355 Q8TCD0_HUMAN (1-107): 1.86e-40: 135: 100.00		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130315 Q8N355_HUMAN (4-107): 9.32e-40: 133: 39.42		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130209 Q6NS95_HUMAN (1-107): 1.83e-35: 122: 35.51		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130206 Q6MZW0_HUMAN (6-100): 5.57e-17: 76.7: 23.23		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130207 Q6N093_HUMAN (7-106): 5.94e-10: 56.5: 27.89		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130254 Q7Z351_HUMAN (2-107): 4.26e-09: 53.8: 25.47		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		382337 HLAA_HUMAN (1-103): 1.41e-37: 131: 21.36		CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74
+	Hs
		382564 HLAA_HUMAN (1-103): 1.41e-37: 131: 21.36		SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27
+	Hs
		488423 HLAC_HUMAN (1-105): 8.82e-37: 128: 21.91		SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27