Interactor 1: IGHE (P01854)
Immunoglobulin heavy constant epsilon (Ig epsilon chain C region) (Ig epsilon chain C region ND)
Gene: IGHE

Interactor 2: FCERA (P12319)
High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)
Gene: FCER1A

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 10917520, 11531339
Identification Methods x-ray crystallography
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~Ig_2, C1-set~Ig_3
Common GO terms GO:0005886 - plasma membrane
GO:0016068 - type I hypersensitivity
GO:0042092 - type 2 immune response
GO:0043303 - mast cell degranulation
GO:0043308 - eosinophil degranulation
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 546
Hs

1 257
+ Hs
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+ Dm
+ Dm
+ Rn
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Ce
+ Mm
+ Dm
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Last updated: 15 Jul 2024