HitPredict

Interactor 1: IGHG2 (P01859)
Immunoglobulin heavy constant gamma 2 (Ig gamma-2 chain C region) (Ig gamma-2 chain C region DOT) (Ig gamma-2 chain C region TIL) (Ig gamma-2 chain C region ZIE)
Gene: IGHG2

Interactor 2: HV431 (P0DP07)
Immunoglobulin heavy variable 4-31
Gene: IGHV4-31

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	C1-set~V-set
Common GO terms	GO:0003823 - antigen binding GO:0005886 - plasma membrane GO:0072562 - blood microparticle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 395 Hs			1 118
+	Hs
		353350 IGHG1_HUMAN (1-395): 9.55e-111: 331: 90.23		HV307_HUMAN (1-118): 2.14e-50: 157: 48.74
+	Hs
		353347 IGHG1_HUMAN (1-395): 9.55e-111: 331: 90.23		HV323_HUMAN (1-118): 8.05e-50: 155: 50.42
+	Hs
		353698 IGHG1_HUMAN (1-395): 9.55e-111: 331: 90.23		Q8N355_HUMAN (1-117): 1.18e-37: 128: 23.93
+	Hs
		353871 IGHG4_HUMAN (1-395): 5.15e-105: 317: 93.18		HV431_HUMAN (1-118): 2.09e-39: 129: 100.00
+	Hs
		353208 IGHG1_HUMAN (1-395): 9.55e-111: 331: 90.23		LV208_HUMAN (1-117): 8.26e-33: 112: 25.64
+	Hs
		353837 IGHG3_HUMAN (1-395): 6.18e-101: 308: 82.06		HV431_HUMAN (1-118): 2.09e-39: 129: 100.00
+	Hs
		353203 IGHG1_HUMAN (1-395): 9.55e-111: 331: 90.23		LV147_HUMAN (1-117): 1.17e-27: 99.6: 23.93
+	Mm
		353202 IGHG1_MOUSE (1-325): 3.91e-71: 227: 63.69		KV3AD_MOUSE (20-118): 1.98e-37: 124: 24.00
+	Hs
		353181 IGHA1_HUMAN (1-370): 2.19e-65: 215: 29.52		KVD40_HUMAN (6-118): 2.18e-38: 126: 25.00
+	Hs
		354141 IGHA1_HUMAN (1-370): 2.19e-65: 215: 29.52		Q9UL92_HUMAN (20-118): 6.58e-36: 120: 46.00
+	Mm
		353221 IGHG1_MOUSE (1-325): 3.91e-71: 227: 63.69		LV1B_MOUSE (1-117): 1.09e-27: 100: 24.79
+	Mm
		353224 IGHG1_MOUSE (1-325): 3.91e-71: 227: 63.69		LV1E_MOUSE (1-117): 1.69e-25: 94.6: 23.08
+	Hs
		353205 IGHA1_HUMAN (1-370): 2.19e-65: 215: 29.52		LV147_HUMAN (1-117): 1.17e-27: 99.6: 23.93
+	Hs
		353180 IGHM_HUMAN (1-383): 3.57e-24: 105: 20.75		KVD40_HUMAN (6-118): 2.18e-38: 126: 25.00
+	Hs
		353349 IGLC1_HUMAN (6-104): 1.64e-10: 59.8: 31.37		HV333_HUMAN (1-118): 1.07e-51: 160: 49.58
+	Hs
		353204 IGHM_HUMAN (1-383): 3.57e-24: 105: 20.75		LV147_HUMAN (1-117): 1.17e-27: 99.6: 23.93
+	Mm
		526804 IGLL1_MOUSE (4-104): 1.96e-10: 62.1: 27.89		VPREB_MOUSE (1-117): 2.5e-43: 140: 25.64
+	Mm
		353201 GCAM_MOUSE (1-103): 7.51e-10: 62: 23.81		KV3A8_MOUSE (20-118): 2.84e-37: 123: 25.00
+	Hs
		353209 IGLC1_HUMAN (6-104): 1.64e-10: 59.8: 31.37		LV208_HUMAN (1-117): 8.26e-33: 112: 25.64