HitPredict

Interactor 1: IGHG3 (P01860)
Immunoglobulin heavy constant gamma 3 (HDC) (Heavy chain disease protein) (Ig gamma-3 chain C region)
Gene: IGHG3

Interactor 2: HV431 (P0DP07)
Immunoglobulin heavy variable 4-31
Gene: IGHV4-31

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	C1-set~V-set
Common GO terms	GO:0003823 - antigen binding GO:0005886 - plasma membrane GO:0072562 - blood microparticle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 446 Hs			1 118
+	Hs
		353350 IGHG1_HUMAN (1-446): 6.57e-137: 400: 84.53		HV307_HUMAN (1-118): 2.14e-50: 157: 48.74
+	Hs
		353347 IGHG1_HUMAN (1-446): 6.57e-137: 400: 84.53		HV323_HUMAN (1-118): 8.05e-50: 155: 50.42
+	Hs
		353698 IGHG1_HUMAN (1-446): 6.57e-137: 400: 84.53		Q8N355_HUMAN (1-117): 1.18e-37: 128: 23.93
+	Hs
		353750 IGHG2_HUMAN (1-446): 1.51e-131: 386: 78.25		HV431_HUMAN (1-118): 2.09e-39: 129: 100.00
+	Hs
		353208 IGHG1_HUMAN (1-446): 6.57e-137: 400: 84.53		LV208_HUMAN (1-117): 8.26e-33: 112: 25.64
+	Hs
		353871 IGHG4_HUMAN (1-446): 1.07e-128: 379: 82.29		HV431_HUMAN (1-118): 2.09e-39: 129: 100.00
+	Hs
		353203 IGHG1_HUMAN (1-446): 6.57e-137: 400: 84.53		LV147_HUMAN (1-117): 1.17e-27: 99.6: 23.93
+	Mm
		353201 GCAM_MOUSE (2-446): 1.88e-122: 363: 60.00		KV3A8_MOUSE (20-118): 2.84e-37: 123: 25.00
+	Mm
		353202 IGHG1_MOUSE (1-376): 6.67e-87: 269: 53.72		KV3AD_MOUSE (20-118): 1.98e-37: 124: 24.00
+	Mm
		353221 IGHG1_MOUSE (1-376): 6.67e-87: 269: 53.72		LV1B_MOUSE (1-117): 1.09e-27: 100: 24.79
+	Mm
		353224 IGHG1_MOUSE (1-376): 6.67e-87: 269: 53.72		LV1E_MOUSE (1-117): 1.69e-25: 94.6: 23.08
+	Hs
		353180 IGHM_HUMAN (2-421): 1.02e-62: 212: 25.57		KVD40_HUMAN (6-118): 2.18e-38: 126: 25.00
+	Hs
		353204 IGHM_HUMAN (2-421): 1.02e-62: 212: 25.57		LV147_HUMAN (1-117): 1.17e-27: 99.6: 23.93
+	Hs
		353181 IGHA1_HUMAN (1-421): 7.69e-52: 181: 27.69		KVD40_HUMAN (6-118): 2.18e-38: 126: 25.00
+	Hs
		354141 IGHA1_HUMAN (1-421): 7.69e-52: 181: 27.69		Q9UL92_HUMAN (20-118): 6.58e-36: 120: 46.00
+	Hs
		353205 IGHA1_HUMAN (1-421): 7.69e-52: 181: 27.69		LV147_HUMAN (1-117): 1.17e-27: 99.6: 23.93
+	Hs
		353349 IGLC1_HUMAN (271-372): 4.72e-30: 114: 32.69		HV333_HUMAN (1-118): 1.07e-51: 160: 49.58
+	Mm
		353343 IGKC_MOUSE (274-374): 1.77e-28: 109: 28.16		HVM02_MOUSE (1-118): 2.93e-43: 140: 40.34
+	Mm
		353344 IGKC_MOUSE (274-374): 1.77e-28: 109: 28.16		HVM03_MOUSE (21-118): 4.17e-40: 131: 44.44
+	Hs
		353209 IGLC1_HUMAN (271-372): 4.72e-30: 114: 32.69		LV208_HUMAN (1-117): 8.26e-33: 112: 25.64