HitPredict

Interactor 1: DRA (P01903)
HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)
Gene: HLA-DRA

Interactor 2: DRB1 (P01911)
HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1)
Gene: HLA-DRB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 1.00 0.834

The method score is based on:

Property Details
Experiments 11432818, 33961781, 7477400
Identification Methods x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~C1-set, C1-set~MHC_II_beta, C1-set~MHC_II_alpha, MHC_II_alpha~MHC_II_beta
Common GO terms GO:0000139 - Golgi membrane
GO:0001772 - immunological synapse
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002469 - myeloid dendritic cell antigen processing and presentation
GO:0002491 - antigen processing and presentation of endogenous peptide antigen via MHC class II
and 27 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024