HitPredict

Interactor 1: DQA1 (P01909)
HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)
Gene: HLA-DQA1

Interactor 2: DQB1 (P01920)
HLA class II histocompatibility antigen, DQ beta 1 chain (MHC class II antigen DQB1)
Gene: HLA-DQB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.908

The method score is based on:

Property Details
Experiments 29997244, 33961781, 17629515, 11376336
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, luminescence based mammalian interactome mapping, solid phase assay, anti tag coimmunoprecipitation, x-ray crystallography
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains C1-set~C1-set, C1-set~MHC_II_beta, C1-set~MHC_II_alpha, MHC_II_alpha~MHC_II_beta
Common GO terms GO:0000139 - Golgi membrane
GO:0002250 - adaptive immune response
GO:0002503 - peptide antigen assembly with MHC class II protein complex
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
and 16 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024