HitPredict

Interactor 1: H2B (P02283)
Histone H2B
Gene: H2B, His2B;

Interactor 2: PARP (P35875)
Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase) (ADPRT) (Poly[ADP-ribose] synthase) (Protein ADP-ribosyltransferase Parp) (EC 2.4.2.-)
Gene: PARP

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	17827147
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 123 Dm			1 994
+	Hs
		1087460 H2B2E_HUMAN (3-123): 9.53e-49: 153: 82.11		PARP2_HUMAN (439-992): 0: 627: 36.51
+	Hs
		707781 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		PARP2_HUMAN (439-992): 0: 627: 36.51
+	Hs
		918755 H2B1C_HUMAN (3-123): 1.51e-48: 153: 81.30		PARP2_HUMAN (439-992): 0: 627: 36.51
+	Hs
		1231259 H2B3B_HUMAN (3-123): 1.14e-46: 148: 81.30		PARP2_HUMAN (439-992): 0: 627: 36.51
+	Hs
		1087515 H2B2E_HUMAN (3-123): 9.53e-49: 153: 82.11		PARP3_HUMAN (472-990): 7.44e-151: 459: 30.20
+	Hs
		1274474 H2B1H_HUMAN (3-123): 5.28e-49: 154: 81.30		PARP4_HUMAN (397-990): 9.12e-123: 413: 19.08
+	Hs
		617984 H2B1O_HUMAN (3-123): 3.29e-49: 154: 82.11		PARP4_HUMAN (397-990): 9.12e-123: 413: 19.08
+	Hs
		241659 H2B1K_HUMAN (3-123): 2.12e-48: 152: 80.49		PARP4_HUMAN (397-990): 9.12e-123: 413: 19.08
+	Hs
		707557 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		DNLI3_HUMAN (4-107): 1.92e-28: 125: 21.05
+	Hs
		836703 H2B1C_HUMAN (3-123): 1.51e-48: 153: 81.30		DNLI3_HUMAN (4-107): 1.92e-28: 125: 21.05
+	Hs
		836738 H2B2E_HUMAN (3-123): 9.53e-49: 153: 82.11		DNLI3_HUMAN (4-107): 1.92e-28: 125: 21.05
+	Hs
		836751 H2B3B_HUMAN (3-123): 1.14e-46: 148: 81.30		DNLI3_HUMAN (4-107): 1.92e-28: 125: 21.05
+	Hs
		455094 H2B1O_HUMAN (3-123): 3.29e-49: 154: 82.11		PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74
+	Hs
		455733 H2B1H_HUMAN (3-123): 5.28e-49: 154: 81.30		PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74
+	Hs
		455136 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74
+	Hs
		455301 H2B1C_HUMAN (3-123): 1.51e-48: 153: 81.30		PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74
+	Hs
		455500 H2B2E_HUMAN (3-123): 9.53e-49: 153: 82.11		PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74
+	Hs
		1087162 H2B2E_HUMAN (3-123): 9.53e-49: 153: 82.11		PAR10_HUMAN (783-987): 6.43e-19: 94.6: 15.35
+	Hs
		455276 H2B1D_HUMAN (3-123): 2.76e-48: 152: 81.30		PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74
+	Hs
		455645 H2B3B_HUMAN (3-123): 1.14e-46: 148: 81.30		PARP1_HUMAN (103-513): 4.94e-19: 94.9: 15.74