HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: MCM2 (P29469)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)
Gene: MCM2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	23499444, 30104407, 21179020
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0005634 - nucleus GO:0031298 - replication fork protection complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 131 Sc			1 868
+	Sc
		355815 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		MCM2_YEAST (18-868): 0: 960: 100.00
+	Hs
		832512 H2B2F_HUMAN (7-128): 7.21e-47: 149: 70.97		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		617935 H2B1O_HUMAN (7-128): 2.09e-46: 148: 70.97		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832673 H2B1M_HUMAN (7-128): 9.18e-47: 148: 69.36		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832497 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		832624 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		707553 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		708456 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		MCM4_HUMAN (19-851): 0: 768: 26.31
+	Hs
		707531 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		MCM4_HUMAN (19-851): 0: 768: 26.31
+	Hs
		708674 H2B2F_HUMAN (7-128): 7.21e-47: 149: 70.97		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		617930 H2B1O_HUMAN (7-128): 2.09e-46: 148: 70.97		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708749 H2B1M_HUMAN (7-128): 9.18e-47: 148: 69.36		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708664 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		708719 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		707532 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		627278 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		MCM3_HUMAN (194-846): 0: 696: 32.39
+	Hs
		1055566 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		MCM6_HUMAN (190-854): 0: 678: 28.51
+	Hs
		1055603 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		MCM6_HUMAN (190-854): 0: 678: 28.51
+	Sc
		355817 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		MCM4_YEAST (38-851): 0: 672: 25.54
+	Sc
		355816 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		MCM5_YEAST (207-848): 1.04e-85: 291: 32.24