HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: RAD16 (P31244)
DNA repair protein RAD16 (EC 3.6.4.-) (ATP-dependent helicase RAD16)
Gene: RAD16

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	37968396, 22199229, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 131 Sc			1 790
+	Sc
		355819 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		RAD16_YEAST (1-790): 0: 641: 100.00
+	Hs
		1307128 H2B1M_HUMAN (7-128): 9.18e-47: 148: 69.36		CHD8_HUMAN (75-788): 1.42e-171: 549: 22.16
+	Hs
		1087418 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		CHD8_HUMAN (75-788): 1.42e-171: 549: 22.16
+	Hs
		707755 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD8_HUMAN (75-788): 1.42e-171: 549: 22.16
+	Hs
		1087449 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		CHD7_HUMAN (23-788): 3.55e-169: 543: 19.45
+	Hs
		707773 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD7_HUMAN (23-788): 3.55e-169: 543: 19.45
+	Hs
		707647 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD9_HUMAN (85-788): 1.15e-155: 504: 21.17
+	Hs
		1055124 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		HLTF_HUMAN (99-787): 2.02e-147: 460: 24.73
+	Hs
		707628 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		HLTF_HUMAN (99-787): 2.02e-147: 460: 24.73
+	Sc
		355822 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		BTAF1_YEAST (126-789): 6.09e-141: 458: 22.22
+	Hs
		1102052 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		ERC6L_HUMAN (114-788): 5.15e-139: 443: 20.11
+	Sc
		355821 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		FUN30_YEAST (177-776): 2.25e-137: 436: 22.82
+	Hs
		1018625 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		CHD3_HUMAN (367-790): 4.85e-63: 232: 18.42
+	Hs
		241517 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		CHD3_HUMAN (367-790): 4.85e-63: 232: 18.42
+	Hs
		707612 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		CHD3_HUMAN (367-790): 4.85e-63: 232: 18.42
+	Hs
		229415 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SMCA5_HUMAN (487-788): 1.93e-58: 217: 20.79
+	Hs
		229458 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		SMCA5_HUMAN (487-788): 1.93e-58: 217: 20.79
+	Hs
		229321 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		SMCA5_HUMAN (487-788): 1.93e-58: 217: 20.79
+	Hs
		1087210 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		SRCAP_HUMAN (620-763): 7.95e-17: 87.8: 35.42
+	Hs
		707663 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		SRCAP_HUMAN (620-763): 7.95e-17: 87.8: 35.42