HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: HDA1 (P53973)
Histone deacetylase HDA1 (EC 3.5.1.98)
Gene: HDA1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	27665728
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 131 Sc			1 706
+	Sc
		355966 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		HDA1_YEAST (1-706): 0: 979: 100.00
+	Hs
		241663 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		HDAC5_HUMAN (19-444): 1.54e-146: 457: 33.33
+	Hs
		1038424 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		HDAC1_HUMAN (64-450): 2.35e-147: 439: 23.70
+	Hs
		707620 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		HDAC1_HUMAN (64-450): 2.35e-147: 439: 23.70
+	Hs
		918340 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		HDAC1_HUMAN (64-450): 2.35e-147: 439: 23.70
+	Hs
		1038530 H2B3B_HUMAN (7-128): 2.3e-44: 143: 64.52		HDAC1_HUMAN (64-450): 2.35e-147: 439: 23.70
+	Sc
		355401 H2B1_YEAST (1-131): 2.54e-44: 143: 100.00		RPD3_YEAST (46-401): 1.41e-139: 417: 24.44
+	Hs
		1270408 H2B1M_HUMAN (7-128): 9.18e-47: 148: 69.36		HDAC2_HUMAN (65-456): 1.84e-134: 406: 23.17
+	Hs
		1087306 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		HDAC2_HUMAN (65-456): 1.84e-134: 406: 23.17
+	Hs
		707699 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		HDAC2_HUMAN (65-456): 1.84e-134: 406: 23.17
+	Hs
		1038606 H2B1A_HUMAN (29-128): 2.91e-32: 112: 80.00		HDAC1_HUMAN (64-450): 2.35e-147: 439: 23.70
+	Hs
		1231218 H2B3B_HUMAN (7-128): 2.3e-44: 143: 64.52		HDAC2_HUMAN (65-456): 1.84e-134: 406: 23.17
+	Hs
		1270409 H2B1L_HUMAN (7-128): 2.46e-44: 142: 70.16		HDAC2_HUMAN (65-456): 1.84e-134: 406: 23.17
+	Hs
		1307130 H2B1M_HUMAN (7-128): 9.18e-47: 148: 69.36		HDAC6_HUMAN (58-438): 1.5e-119: 388: 34.12
+	Hs
		241656 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		HDAC6_HUMAN (58-438): 1.5e-119: 388: 34.12
+	Hs
		707778 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		HDAC6_HUMAN (58-438): 1.5e-119: 388: 34.12
+	Hs
		886211 H2B1D_HUMAN (7-128): 1.99e-45: 145: 70.16		HDAC6_HUMAN (58-438): 1.5e-119: 388: 34.12
+	Hs
		1307148 H2B1L_HUMAN (7-128): 2.46e-44: 142: 70.16		HDAC6_HUMAN (58-438): 1.5e-119: 388: 34.12
+	Sp
		140569 H2B1_SCHPO (3-130): 5.07e-44: 141: 78.91		PHD1_SCHPO (65-403): 4.26e-36: 143: 28.20
+	Sc
		355947 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		HOS2_YEAST (62-385): 1.06e-30: 127: 27.27