HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: YL455 (Q06188)
PWWP domain-containing protein YLR455W
Gene: YLR455W

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	25473596, 37968396, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0005634 - nucleus
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 131 Sc			1 304
+	Sc
		356017 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		YL455_YEAST (1-304): 2.2e-121: 351: 100.00
+	Sp
		223463 H2B1_SCHPO (3-130): 5.07e-44: 141: 78.91		PDP1_SCHPO (5-290): 3.72e-87: 266: 21.73
+	Hs
		1087155 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		GLYR1_HUMAN (4-184): 2.55e-64: 213: 19.02
+	Hs
		918404 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		GLYR1_HUMAN (4-184): 2.55e-64: 213: 19.02
+	Hs
		331825 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		NSD2_HUMAN (3-159): 1.74e-11: 66.8: 13.29
+	Hs
		331768 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		NSD2_HUMAN (3-159): 1.74e-11: 66.8: 13.29
+	Hs
		1087385 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		NSD3_HUMAN (5-199): 4.82e-11: 65.7: 15.24
+	Hs
		707738 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		NSD3_HUMAN (5-199): 4.82e-11: 65.7: 15.24
+	Hs
		918663 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		NSD3_HUMAN (5-199): 4.82e-11: 65.7: 15.24
+	Hs
		1087342 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		NSD1_HUMAN (9-119): 3e-10: 63.4: 19.47
+	Hs
		1274410 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		NSD1_HUMAN (9-119): 3e-10: 63.4: 19.47
+	Hs
		918612 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		NSD1_HUMAN (9-119): 3e-10: 63.4: 19.47