HitPredict

Interactor 1: H2B1 (P02293)
Histone H2B.1 (Suppressor of Ty protein 12)
Gene: HTB1

Interactor 2: BRE1 (Q07457)
E3 ubiquitin-protein ligase BRE1 (EC 2.3.2.27) (Brefeldin A-sensitivity protein 1) (RING-type E3 ubiquitin transferase BRE1)
Gene: BRE1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	25548288, 27601672, 37230987, 37633270, 37034759
Identification Methods	pull down, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 131 Sc			1 700
+	Sc
		356028 H2B2_YEAST (1-131): 1.46e-45: 146: 96.95		BRE1_YEAST (1-700): 9.24e-50: 187: 100.00
+	Hs
		1129870 H2B2F_HUMAN (7-128): 7.21e-47: 149: 70.97		MRCKB_HUMAN (67-632): 1.66e-38: 156: 12.56
+	Hs
		1274489 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		MRCKB_HUMAN (67-632): 1.66e-38: 156: 12.56
+	Hs
		256269 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		BRE1B_HUMAN (315-700): 1.27e-34: 143: 20.73
+	Hs
		1087184 H2B2E_HUMAN (7-128): 3.68e-46: 147: 70.97		BRE1A_HUMAN (60-700): 2.47e-34: 142: 15.11
+	Hs
		256219 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		BRE1B_HUMAN (315-700): 1.27e-34: 143: 20.73
+	Hs
		707654 H2B1B_HUMAN (7-128): 1.18e-45: 146: 70.16		BRE1A_HUMAN (60-700): 2.47e-34: 142: 15.11
+	Hs
		148588 H2BFS_HUMAN (7-128): 4.79e-46: 147: 68.55		CTRO_HUMAN (137-615): 1.43e-16: 86.6: 10.00
+	Hs
		724951 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Hs
		148194 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		CTRO_HUMAN (137-615): 1.43e-16: 86.6: 10.00
+	Hs
		148290 H2B1J_HUMAN (7-128): 5.77e-46: 146: 70.16		CTRO_HUMAN (137-615): 1.43e-16: 86.6: 10.00
+	Hs
		241463 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Hs
		724751 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Hs
		725214 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		MYH10_HUMAN (245-667): 3.3e-16: 85.5: 10.88
+	Hs
		241464 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		MYH10_HUMAN (245-667): 3.3e-16: 85.5: 10.88
+	Hs
		725133 H2B1C_HUMAN (7-128): 6.8e-46: 146: 70.97		MYH10_HUMAN (245-667): 3.3e-16: 85.5: 10.88
+	Hs
		1274476 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		MYH2_HUMAN (319-661): 1.17e-13: 77: 11.59
+	Hs
		621614 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		LAMA2_HUMAN (324-642): 2.86e-13: 75.8: 12.22
+	Hs
		551798 H2B1H_HUMAN (7-128): 3.89e-46: 147: 70.97		DESP_HUMAN (127-645): 9.85e-10: 64.2: 14.61
+	Hs
		241465 H2B1K_HUMAN (7-128): 1.06e-45: 146: 70.16		MYH11_HUMAN (394-666): 8.64e-10: 64.7: 13.41