HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: SUV39 (P45975)
Histone-lysine N-methyltransferase Su(var)3-9 (EC 2.1.1.355) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (Lysine N-methyltransferase 1) (Protein suppressor of variegation 3-9)
Gene: Su(var)3-9

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.80	0.756

Property	Details
Experiments	11867540, 17434130, 23559249
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 635
+	Hs
		935237 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV92_HUMAN (207-634): 1.5e-120: 366: 32.79
+	At
		886462 H33_ARATH (1-136): 4.35e-62: 188: 96.32		SUVH4_ARATH (70-635): 6.97e-113: 353: 17.74
+	Hs
		203659 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV91_HUMAN (209-635): 2.01e-111: 342: 33.33
+	Hs
		203722 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		SUV91_HUMAN (209-635): 2.01e-111: 342: 33.33
+	Mm
		952777 H33_MOUSE (1-136): 1.59e-61: 186: 97.06		EHMT2_MOUSE (311-631): 1.08e-90: 307: 29.79
+	Hs
		935126 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EHMT2_HUMAN (311-631): 2.44e-89: 303: 29.48
+	Hs
		1086279 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EHMT2_HUMAN (311-631): 2.44e-89: 303: 29.48
+	Hs
		1174632 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		EHMT2_HUMAN (311-631): 2.44e-89: 303: 29.48
+	Hs
		935251 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EHMT1_HUMAN (336-631): 1.62e-84: 290: 30.90
+	Hs
		1086320 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EHMT1_HUMAN (336-631): 1.62e-84: 290: 30.90
+	Hs
		935204 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SETD2_HUMAN (245-634): 1.24e-78: 274: 21.29
+	Hs
		1086306 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		SETD2_HUMAN (245-634): 1.24e-78: 274: 21.29
+	Hs
		935276 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		ASH1L_HUMAN (303-634): 1.54e-71: 254: 19.94
+	Hs
		935129 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD1_HUMAN (328-634): 3.9e-67: 241: 23.40
+	Hs
		934804 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EZH2_HUMAN (321-622): 3.92e-69: 240: 22.36
+	Hs
		1086280 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		NSD1_HUMAN (328-634): 3.9e-67: 241: 23.40
+	Hs
		1079993 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EZH2_HUMAN (321-622): 3.92e-69: 240: 22.36
+	Mm
		952747 H33_MOUSE (1-136): 1.59e-61: 186: 97.06		EZH2_MOUSE (321-622): 1.34e-68: 239: 22.05
+	Mm
		952754 H33_MOUSE (1-136): 1.59e-61: 186: 97.06		Q6AXH7_MOUSE (321-622): 2.33e-68: 238: 22.05
+	Dm
		115784 H3_DROME (1-136): 3.73e-61: 186: 100.00		M9PGH7_DROME (365-631): 1.74e-65: 236: 30.29