HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: SETB1 (Q32KD2)
Histone-lysine N-methyltransferase eggless (EC 2.1.1.355) (SETDB1 homolog)
Gene: egg

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	20498723
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005700 - polytene chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 1262
+	Hs
		935251 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EHMT1_HUMAN (1085-1258): 6.22e-45: 180: 22.91
+	Hs
		1086320 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EHMT1_HUMAN (1085-1258): 6.22e-45: 180: 22.91
+	Hs
		935126 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EHMT2_HUMAN (1100-1258): 1.38e-44: 178: 21.95
+	Hs
		203659 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV91_HUMAN (1046-1262): 1.72e-47: 177: 17.94
+	Hs
		952633 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		EHMT1_HUMAN (1085-1258): 6.22e-45: 180: 22.91
+	Hs
		1086279 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EHMT2_HUMAN (1100-1258): 1.38e-44: 178: 21.95
+	Mm
		952777 H33_MOUSE (1-136): 1.59e-61: 186: 97.06		EHMT2_MOUSE (1100-1258): 9.88e-45: 179: 21.95
+	Hs
		1174632 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		EHMT2_HUMAN (1100-1258): 1.38e-44: 178: 21.95
+	Hs
		952553 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		EHMT2_HUMAN (1100-1258): 1.38e-44: 178: 21.95
+	Hs
		203664 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		SUV91_HUMAN (1046-1262): 1.72e-47: 177: 17.94
+	Hs
		203722 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		SUV91_HUMAN (1046-1262): 1.72e-47: 177: 17.94
+	Hs
		935237 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV92_HUMAN (1097-1261): 1.97e-46: 174: 21.81
+	Hs
		952627 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		SUV92_HUMAN (1097-1261): 1.97e-46: 174: 21.81
+	Dm
		356118 H3_DROME (1-136): 3.73e-61: 186: 100.00		ASH1_DROME (1063-1261): 1.58e-41: 169: 16.43
+	At
		886462 H33_ARATH (1-136): 4.35e-62: 188: 96.32		SUVH4_ARATH (1060-1262): 1.9e-39: 158: 20.49
+	Hs
		934780 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SETB1_HUMAN (1085-1262): 7.04e-36: 150: 44.94
+	Hs
		1065636 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		SETB1_HUMAN (1085-1262): 7.04e-36: 150: 44.94
+	Dm
		115784 H3_DROME (1-136): 3.73e-61: 186: 100.00		M9PGH7_DROME (1082-1258): 2.92e-33: 142: 18.23
+	Dm
		356073 H3_DROME (1-136): 3.73e-61: 186: 100.00		SUV39_DROME (1129-1262): 8.26e-31: 132: 23.78
+	Hs
		952574 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		SETB2_HUMAN (1173-1262): 2.84e-26: 118: 51.11