HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: KDM4A (Q9V333)
Probable lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (Probable JmjC domain-containing histone demethylation protein 3A) (Probable [histone H3]-trimethyl-L-lysine(36) demethylase 4A) (Probable [histone H3]-trimethyl-L-lysine(9) demethylase 4A)
Gene: KDM4A

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19061644
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 495
+	Hs
		256961 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM4A_HUMAN (10-465): 0: 576: 50.54
+	Hs
		256973 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KDM4A_HUMAN (10-465): 0: 576: 50.54
+	Hs
		256963 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		KDM4A_HUMAN (10-465): 0: 576: 50.54
+	Hs
		301134 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM4B_HUMAN (4-386): 0: 541: 57.70
+	Hs
		301136 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		KDM4B_HUMAN (4-386): 0: 541: 57.70
+	Hs
		301146 H3C_HUMAN (1-136): 8.83e-59: 179: 94.12		KDM4B_HUMAN (4-386): 0: 541: 57.70
+	Dm
		356098 H3_DROME (1-136): 3.73e-61: 186: 100.00		KDM4B_DROME (11-405): 0: 528: 62.96
+	Hs
		935232 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM4C_HUMAN (6-385): 4.39e-175: 521: 56.77
+	Hs
		1174653 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		KDM4C_HUMAN (6-385): 4.39e-175: 521: 56.77
+	Hs
		952622 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		KDM4C_HUMAN (6-385): 4.39e-175: 521: 56.77
+	Sp
		457185 H31_SCHPO (1-136): 2.22e-59: 181: 91.91		LID2_SCHPO (38-327): 2.77e-70: 245: 19.29
+	Sp
		498409 H33_SCHPO (1-136): 4.37e-58: 177: 91.18		LID2_SCHPO (38-327): 2.77e-70: 245: 19.29
+	Hs
		1086304 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KDM5D_HUMAN (4-124): 1.42e-15: 82.1: 23.97
+	Hs
		935339 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM5B_HUMAN (14-124): 1.86e-14: 78.6: 21.62
+	Dm
		356114 H3_DROME (1-136): 3.73e-61: 186: 100.00		KDM5_DROME (9-124): 2.48e-15: 81.3: 26.72
+	Hs
		782353 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		KDM5C_HUMAN (4-124): 2.8e-15: 80.9: 23.14
+	Hs
		666522 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM5A_HUMAN (14-124): 8.36e-14: 76.3: 21.43
+	Hs
		666535 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KDM5A_HUMAN (14-124): 8.36e-14: 76.3: 21.43
+	Hs
		666523 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		KDM5A_HUMAN (14-124): 8.36e-14: 76.3: 21.43
+	Hs
		666539 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		KDM5A_HUMAN (14-124): 8.36e-14: 76.3: 21.43