HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: SCM (Q9VHA0)
Polycomb protein Scm (Sex comb on midleg protein)
Gene: SCM

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.60	0.568

Property	Details
Experiments	17932512
Identification Methods	pull down, x-ray crystallography, isothermal titration calorimetry
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005700 - polytene chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 877
+	Hs
		935383 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SCML2_HUMAN (140-869): 0: 586: 29.86
+	Hs
		952706 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		SCML2_HUMAN (140-869): 0: 586: 29.86
+	Hs
		935122 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		LMBL3_HUMAN (272-874): 1.31e-134: 422: 17.78
+	Hs
		828347 CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00		LMBL3_HUMAN (272-874): 1.31e-134: 422: 17.78
+	Hs
		935109 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SCMH1_HUMAN (275-869): 4.87e-108: 348: 18.43
+	Hs
		952544 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		SCMH1_HUMAN (275-869): 4.87e-108: 348: 18.43
+	Hs
		935423 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		LMBL1_HUMAN (271-853): 4.27e-104: 343: 15.26
+	Hs
		935083 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		LMBL2_HUMAN (164-717): 2.33e-58: 214: 16.55
+	Hs
		1086263 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		LMBL2_HUMAN (164-717): 2.33e-58: 214: 16.55
+	Dm
		356111 H3_DROME (1-136): 3.73e-61: 186: 100.00		SMBT_DROME (158-564): 4.6e-57: 215: 19.11
+	Hs
		952525 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		LMBL2_HUMAN (164-717): 2.33e-58: 214: 16.55
+	Hs
		934644 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		PHC1_HUMAN (391-869): 1.19e-53: 204: 14.37
+	Hs
		1086210 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		PHC2_HUMAN (377-869): 1.02e-49: 191: 13.59
+	Hs
		934999 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		PHC3_HUMAN (559-869): 2.97e-38: 156: 15.67
+	Hs
		1086225 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		PHC3_HUMAN (559-869): 2.97e-38: 156: 15.67
+	Hs
		828293 CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00		PHC2_HUMAN (377-869): 1.02e-49: 191: 13.59
+	Hs
		934900 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SAMD1_HUMAN (678-869): 2.04e-33: 138: 18.37
+	Hs
		952419 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		SAMD1_HUMAN (678-869): 2.04e-33: 138: 18.37
+	Hs
		935345 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SMBT1_HUMAN (160-274): 7.48e-25: 113: 36.21
+	Hs
		1086345 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		SMBT1_HUMAN (160-274): 7.48e-25: 113: 36.21