HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: KDM5 (Q9VMJ7)
Lysine-specific demethylase 5 (EC 1.14.11.67) (Histone demethylase lid) (Jumonji/ARID domain-containing protein lid) (Protein little imaginal disks) (lid) (Retinoblastoma-binding protein 2 homolog) ([histone H3]-trimethyl-L-lysine(4) demethylase Kdm5)
Gene: KDM5

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	21124823, 17351631
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 1838
+	Hs
		666522 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM5A_HUMAN (149-1807): 0: 938: 38.12
+	Hs
		666535 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KDM5A_HUMAN (149-1807): 0: 938: 38.12
+	Hs
		666539 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		KDM5A_HUMAN (149-1807): 0: 938: 38.12
+	Hs
		782353 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		KDM5C_HUMAN (150-1652): 0: 903: 39.87
+	Hs
		1086304 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KDM5D_HUMAN (150-1642): 0: 876: 39.97
+	Hs
		183098 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM6A_HUMAN (5-887): 4.83e-109: 383: 11.05
+	Hs
		183122 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KDM6A_HUMAN (5-887): 4.83e-109: 383: 11.05
+	Hs
		183127 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		KDM6A_HUMAN (5-887): 4.83e-109: 383: 11.05
+	Hs
		935232 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM4C_HUMAN (474-1150): 2.93e-95: 336: 18.48
+	Hs
		1174653 H32_HUMAN (1-136): 3.73e-61: 186: 100.00		KDM4C_HUMAN (474-1150): 2.93e-95: 336: 18.48
+	Hs
		165840 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM6B_HUMAN (61-895): 2.32e-90: 328: 12.66
+	Hs
		256961 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM4A_HUMAN (474-1374): 8.35e-92: 325: 16.86
+	Hs
		256973 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		KDM4A_HUMAN (474-1374): 8.35e-92: 325: 16.86
+	Hs
		256963 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		KDM4A_HUMAN (474-1374): 8.35e-92: 325: 16.86
+	Mm
		952745 H33_MOUSE (1-136): 1.59e-61: 186: 97.06		KDM6B_MOUSE (61-895): 1.79e-88: 322: 12.44
+	Hs
		301134 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM4B_HUMAN (474-828): 4.31e-89: 318: 24.59
+	Hs
		301136 H33_HUMAN (1-136): 1.59e-61: 186: 97.06		KDM4B_HUMAN (474-828): 4.31e-89: 318: 24.59
+	Dm
		356098 H3_DROME (1-136): 3.73e-61: 186: 100.00		KDM4B_DROME (474-787): 3.53e-87: 299: 28.70
+	Dm
		356095 H3_DROME (1-136): 3.73e-61: 186: 100.00		KDM4A_DROME (474-874): 2.56e-86: 293: 22.65
+	Hs
		935339 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		KDM5B_HUMAN (1098-1806): 7.14e-33: 142: 12.82