HitPredict

Interactor 1: H3 (P02299)
Histone H3
Gene: H3, His3;

Interactor 2: ASH1 (Q9VW15)
Histone-lysine N-methyltransferase ash1 (EC 2.1.1.354) (Absent small and homeotic disks protein 1) (Lysine N-methyltransferase 2H)
Gene: ASH1

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	13679578, 17544230
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	AWS~Histone, BAH~Histone, Histone~SET
Common GO terms	GO:0000785 - chromatin GO:0005700 - polytene chromosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Dm			1 2226
+	Hs
		935276 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		ASH1L_HUMAN (934-2212): 0: 671: 30.89
+	Hs
		935204 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SETD2_HUMAN (957-1988): 6.03e-101: 366: 15.80
+	At
		886462 H33_ARATH (1-136): 4.35e-62: 188: 96.32		SUVH4_ARATH (970-1528): 1.03e-98: 334: 16.06
+	Hs
		934698 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EP300_HUMAN (1571-2106): 3.35e-81: 301: 11.19
+	Hs
		998779 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EP300_HUMAN (1571-2106): 3.35e-81: 301: 11.19
+	Hs
		935066 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		CBP_HUMAN (1561-2106): 2.95e-80: 298: 10.51
+	Hs
		934804 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EZH2_HUMAN (1026-1514): 3.43e-84: 296: 18.31
+	Hs
		1079993 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		EZH2_HUMAN (1026-1514): 3.43e-84: 296: 18.31
+	Hs
		319165 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		BRD1_HUMAN (1145-1813): 3.43e-81: 294: 13.81
+	Hs
		319213 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		BRD1_HUMAN (1145-1813): 3.43e-81: 294: 13.81
+	Hs
		935129 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD1_HUMAN (1283-1584): 2.3e-78: 292: 32.68
+	Hs
		331780 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD2_HUMAN (1284-1582): 3.61e-76: 282: 31.02
+	Hs
		331823 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		NSD2_HUMAN (1284-1582): 3.61e-76: 282: 31.02
+	Hs
		935205 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		NSD3_HUMAN (1284-1569): 1.8e-75: 280: 32.76
+	Hs
		203659 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV91_HUMAN (1174-1530): 2.88e-79: 270: 19.85
+	Hs
		935237 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		SUV92_HUMAN (1188-1530): 6.17e-78: 266: 19.69
+	Hs
		935126 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EHMT2_HUMAN (1268-1554): 7.22e-71: 264: 21.71
+	Hs
		935251 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		EHMT1_HUMAN (1319-1550): 3.7e-61: 234: 25.76
+	Hs
		934930 H31_HUMAN (1-136): 1.98e-62: 189: 99.27		PB1_HUMAN (1567-2188): 2.97e-16: 87.8: 9.50
+	Hs
		1086201 H31T_HUMAN (1-136): 8.3e-62: 187: 96.32		PB1_HUMAN (1567-2188): 2.97e-16: 87.8: 9.50