HitPredict

Interactor 1: H4 (P02309)
Histone H4
Gene: HHF1

Interactor 2: SIR2 (P06700)
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)
Gene: SIR2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.726

Property	Details
Experiments	30455303, 10693811, 17889663, 19217406, 22654676, 21179020
Identification Methods	pull down, enzymatic study, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 103 Sc			1 562
+	Sp
		293881 H4_SCHPO (18-103): 2.79e-41: 133: 90.70		SIR2_SCHPO (207-536): 3.23e-118: 359: 41.27
+	Hs
		918008 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SIR3_HUMAN (241-545): 2.18e-101: 313: 32.59
+	Hs
		917994 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SIR7_HUMAN (174-535): 1.51e-93: 293: 19.30
+	Hs
		917598 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SIR6_HUMAN (246-529): 2.2e-81: 260: 21.95
+	Sc
		356626 H4_YEAST (1-103): 5.28e-47: 147: 100.00		HST3_YEAST (240-520): 6.42e-70: 233: 27.19