HitPredict

Interactor 1: H4 (P02309)
Histone H4
Gene: HHF1

Interactor 2: MCM2 (P29469)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2)
Gene: MCM2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.906

Property	Details
Experiments	23499444, 30104407, 37850662, 38713623, 21179020
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CENP-T_C~MCM2_N
Common GO terms	GO:0005634 - nucleus GO:0031298 - replication fork protection complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 103 Sc			1 868
+	Hs
		832321 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		MCM2_HUMAN (16-865): 0: 933: 46.96
+	Hs
		708413 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		MCM4_HUMAN (19-851): 0: 768: 26.31
+	Hs
		708595 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		MCM5_HUMAN (206-863): 0: 718: 32.33
+	Hs
		627231 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		MCM3_HUMAN (194-846): 0: 696: 32.39
+	Sc
		356306 H4_YEAST (1-103): 5.28e-47: 147: 100.00		MCM4_YEAST (38-851): 0: 672: 25.54
+	Hs
		917263 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		MCM6_HUMAN (190-854): 0: 678: 28.51
+	Sc
		356267 H4_YEAST (1-103): 5.28e-47: 147: 100.00		MCM3_YEAST (305-833): 2.8e-87: 300: 37.65
+	Sc
		356303 H4_YEAST (1-103): 5.28e-47: 147: 100.00		MCM5_YEAST (207-848): 1.04e-85: 291: 32.24