HitPredict

Interactor 1: H4 (P02309)
Histone H4
Gene: HHF1

Interactor 2: SET2 (P46995)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.359) (Lysine N-methyltransferase 3) (SET domain-containing protein 2)
Gene: SET2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	18923077, 20139424, 22199229, 21179020
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 103 Sc			1 733
+	Hs
		917762 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		NSD1_HUMAN (32-701): 3.04e-130: 429: 18.48
+	Hs
		917878 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SETD2_HUMAN (38-725): 2.75e-125: 414: 22.38
+	Hs
		331767 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		NSD2_HUMAN (33-402): 2.3e-83: 290: 25.07
+	Hs
		917879 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		NSD3_HUMAN (5-428): 2.56e-81: 284: 21.88
+	Hs
		917760 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		EHMT2_HUMAN (8-258): 7.22e-76: 268: 22.83
+	Hs
		917944 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		EHMT1_HUMAN (13-277): 6.04e-76: 268: 21.38
+	Hs
		917338 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		EZH2_HUMAN (63-243): 1.01e-60: 219: 31.77
+	Hs
		917145 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		KMT2A_HUMAN (112-259): 5.31e-15: 81.6: 31.54