HitPredict

Interactor 1: H4 (P02309)
Histone H4
Gene: HHF1

Interactor 2: INO80 (P53115)
Chromatin-remodeling ATPase INO80 (EC 3.6.4.-) (Inositol-requiring protein 80)
Gene: INO80

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	15607974, 17693258, 24034245, 21179020
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CENP-T_C~Helicase_C, CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 103 Sc			1 1489
+	Sc
		356721 H4_YEAST (1-103): 5.28e-47: 147: 100.00		SWR1_YEAST (63-1474): 1.38e-177: 573: 21.29
+	Hs
		917182 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD3_HUMAN (1116-1487): 5.19e-83: 304: 23.71
+	Hs
		918062 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD7_HUMAN (1162-1486): 4.59e-79: 292: 25.51
+	Hs
		229352 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SMCA5_HUMAN (1122-1487): 3.9e-80: 289: 27.49
+	Hs
		917965 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD8_HUMAN (1162-1486): 1.91e-75: 280: 24.93
+	Hs
		846914 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SMCA4_HUMAN (1133-1475): 1.41e-75: 279: 24.72
+	Hs
		917635 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD6_HUMAN (1114-1486): 1.04e-74: 278: 23.72
+	Hs
		917277 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD4_HUMAN (1157-1481): 9.65e-73: 271: 25.96
+	Hs
		917364 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD9_HUMAN (1162-1486): 2.18e-72: 270: 24.64
+	Sc
		356774 H4_YEAST (1-103): 5.28e-47: 147: 100.00		ISW2_YEAST (1292-1483): 1.06e-66: 249: 43.01
+	Dm
		950383 H4_DROME (18-103): 2.42e-41: 133: 90.70		ISWI_DROME (1293-1481): 2.19e-69: 256: 43.68
+	Hs
		917147 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		ERCC6_HUMAN (1215-1481): 8.07e-65: 245: 28.47
+	Sc
		356424 H4_YEAST (1-103): 5.28e-47: 147: 100.00		ISW1_YEAST (1314-1448): 6.51e-34: 144: 52.21
+	Hs
		918125 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		INO80_HUMAN (1016-1217): 8.86e-30: 131: 5.37
+	Hs
		917476 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SRCAP_HUMAN (918-1236): 2.42e-15: 84.3: 10.15