HitPredict

Interactor 1: H4 (P02309)
Histone H4
Gene: HHF1

Interactor 2: IRC20 (Q06554)
Uncharacterized ATP-dependent helicase IRC20 (EC 3.6.1.-) (Increased recombination centers protein 20)
Gene: IRC20

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	11805837, 24155900, 37968396, 22199229
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~Helicase_C, CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 103 Sc			1 1556
+	Hs
		917182 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD3_HUMAN (925-1556): 1.26e-98: 354: 11.47
+	Hs
		229352 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SMCA5_HUMAN (954-1555): 1.14e-98: 344: 11.88
+	Hs
		918062 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD7_HUMAN (947-1554): 5.71e-95: 343: 9.71
+	Dm
		950383 H4_DROME (18-103): 2.42e-41: 133: 90.70		ISWI_DROME (944-1555): 7.04e-98: 342: 11.46
+	Hs
		917277 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD4_HUMAN (912-1556): 9.85e-95: 341: 11.21
+	Hs
		917635 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD6_HUMAN (942-1554): 6.1e-92: 333: 10.56
+	Hs
		917364 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD9_HUMAN (899-1554): 1.83e-87: 319: 11.49
+	Hs
		846914 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SMCA4_HUMAN (998-1541): 4.04e-84: 307: 14.38
+	Hs
		917261 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		HLTF_HUMAN (266-712): 1.61e-80: 290: 21.62
+	Sc
		356248 H4_YEAST (1-103): 5.28e-47: 147: 100.00		SNF2_YEAST (882-1556): 6.24e-69: 259: 14.15
+	Hs
		917965 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD8_HUMAN (899-1553): 4.71e-71: 266: 11.41
+	Sc
		356774 H4_YEAST (1-103): 5.28e-47: 147: 100.00		ISW2_YEAST (1247-1556): 6.02e-56: 215: 16.20
+	Hs
		151483 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		CHD2_HUMAN (1200-1555): 5.42e-58: 224: 15.17
+	Sc
		356309 H4_YEAST (1-103): 5.28e-47: 147: 100.00		RAD16_YEAST (1239-1511): 6.46e-48: 187: 21.00
+	Hs
		917287 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		SHPRH_HUMAN (1209-1541): 1.25e-43: 177: 23.62
+	Hs
		918143 H4_HUMAN (18-103): 1.92e-41: 133: 90.70		TTF2_HUMAN (1298-1514): 2.2e-43: 175: 22.37
+	Sc
		356315 H4_YEAST (1-103): 5.28e-47: 147: 100.00		BTAF1_YEAST (1295-1541): 2.64e-30: 133: 17.15
+	Sp
		194289 H4_SCHPO (18-103): 2.79e-41: 133: 90.70		FFT3_SCHPO (386-914): 8.11e-26: 118: 16.42
+	Sc
		356350 H4_YEAST (1-103): 5.28e-47: 147: 100.00		CHD1_YEAST (387-687): 2.43e-19: 97.2: 15.26
+	Sp
		144535 H4_SCHPO (18-103): 2.79e-41: 133: 90.70		HRP3_SCHPO (387-780): 4.43e-18: 93: 14.60