Interactor 1: P53 (P02340)
Cellular tumor antigen p53 (Tumor suppressor p53)
Gene: Tp53

Interactor 2: P53 (P02340)
Cellular tumor antigen p53 (Tumor suppressor p53)
Gene: Tp53

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.85 1.00 0.923

The method score is based on:

Property Details
Experiments 8035799, 16717092, 11152481, 20211142, 12514174, 25119037
Identification Methods biochemical, x-ray crystallography, two hybrid, anti tag coimmunoprecipitation
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains P53~P53, P53~P53_tetramer, P53_tetramer~P53_tetramer
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000423 - mitophagy
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
and 182 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 390
Mm

1 390
+ Hs
+ Mm
+ Mm
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+ Hs
+ Mm
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+ Mm
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+ Mm
+ Dr
+ Dr
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024