Interactor 1: P53 (P02340)
Cellular tumor antigen p53 (Tumor suppressor p53)
Gene: Tp53
Interactor 2: MDM2 (P23804)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Species: Mus musculus
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 1.00 | 0.993 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 9732264, 11953423, 25732823, 14555661, 30545932, 18309296, 17936560, 17086174, 20697359, 22216266, 20818388, 22666487, 22805162, 8058315, 10205143, 10706102, 20832751, 30578299, 18566590, 34569407 and 12 others
more... |
| Identification Methods | affinity chromatography technology, pull down, unspecified method, enzymatic study, two hybrid, anti bait coimmunoprecipitation, coimmunoprecipitation, tandem affinity purification, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | P53_TAD~SWIB |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005730 - nucleolus GO:0005737 - cytoplasm and 17 others more... |
| Homologous interactions | 10 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
