HitPredict - High confidence protein-protein interactions

Interactor 1: P53 (P02340)
Cellular tumor antigen p53 (Tumor suppressor p53)
Gene: Tp53

Interactor 2: P73 (Q9JJP2)
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
Gene: Tp73

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	20211142, 23251530
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	P53~P53, P53~P53_tetramer, P53_tetramer~P53_tetramer
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity and 12 others more... GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0006974 - DNA damage response GO:0007346 - regulation of mitotic cell cycle GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043065 - positive regulation of apoptotic process GO:0043523 - regulation of neuron apoptotic process GO:0043565 - sequence-specific DNA binding GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051262 - protein tetramerization
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1	390
Mm

1	631

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024