HitPredict

Interactor 1: CO1A1 (P02452)
Collagen alpha-1(I) chain (Alpha-1 type I collagen)
Gene: COL1A1

Interactor 2: FINC (P02751)
Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
Gene: FN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	20541508, 26848503, 25290767
Identification Methods	classical fluorescence spectroscopy, cross-linking study, fluorescence polarization spectroscopy
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002020 - protease binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005788 - endoplasmic reticulum lumen GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1464 Hs			1 2477
+	Hs
		362809 CO5A1_HUMAN (3-654): 6.99e-36: 151: 36.76		FINC_HUMAN (1-2477): 0: 1538: 100.00
+	Hs
		363093 CO7A1_HUMAN (2-190): 2.11e-11: 71.4: 19.70		FINC_HUMAN (1-2477): 0: 1538: 100.00
+	Hs
		358498 CO1A1_HUMAN (1-1464): 0: 674: 100.00		CO7A1_HUMAN (1981-2282): 5e-21: 104: 19.87
+	Hs
		358454 CO1A1_HUMAN (1-1464): 0: 674: 100.00		MMP2_HUMAN (342-404): 1.25e-15: 85.1: 55.56
+	Hs
		596152 CO5A1_HUMAN (3-654): 6.99e-36: 151: 36.76		TENA_HUMAN (1508-2390): 2.36e-71: 269: 17.23
+	Hs
		358660 CO4A1_HUMAN (6-554): 2.86e-65: 247: 33.56		CO7A1_HUMAN (1981-2282): 5e-21: 104: 19.87
+	Hs
		358647 CO4A1_HUMAN (6-554): 2.86e-65: 247: 33.56		MMP2_HUMAN (342-404): 1.25e-15: 85.1: 55.56
+	Hs
		358650 CO4A1_HUMAN (6-554): 2.86e-65: 247: 33.56		MMP9_HUMAN (301-404): 2.05e-14: 81.3: 42.31
+	Mm
		1144386 CO7A1_MOUSE (775-1266): 1.26e-36: 154: 29.51		CO7A1_MOUSE (1981-2291): 4.47e-24: 114: 19.62
+	Hs
		439227 CO5A1_HUMAN (3-654): 6.99e-36: 151: 36.76		MMP2_HUMAN (342-404): 1.25e-15: 85.1: 55.56
+	Hs
		540415 CO5A1_HUMAN (3-654): 6.99e-36: 151: 36.76		MMP9_HUMAN (301-404): 2.05e-14: 81.3: 42.31
+	Hs
		439240 CO4A6_HUMAN (8-289): 5.07e-23: 109: 25.25		MMP2_HUMAN (342-404): 1.25e-15: 85.1: 55.56
+	Hs
		358587 CO2A1_HUMAN (3-246): 5.59e-17: 89.5: 27.24		MMP2_HUMAN (342-404): 1.25e-15: 85.1: 55.56
+	Hs
		358595 CO2A1_HUMAN (3-246): 5.59e-17: 89.5: 27.24		MMP9_HUMAN (301-404): 2.05e-14: 81.3: 42.31
+	Hs
		439220 CO4A2_HUMAN (3-160): 2e-11: 71.4: 21.95		MMP2_HUMAN (342-404): 1.25e-15: 85.1: 55.56
+	Hs
		441053 CO4A2_HUMAN (3-160): 2e-11: 71.4: 21.95		MMP9_HUMAN (301-404): 2.05e-14: 81.3: 42.31
+	Hs
		436001 CO1A2_HUMAN (5-178): 4.37e-09: 63.7: 22.41		MMP2_HUMAN (342-404): 1.25e-15: 85.1: 55.56
+	Hs
		436005 CO1A2_HUMAN (5-178): 4.37e-09: 63.7: 22.41		MMP9_HUMAN (301-404): 2.05e-14: 81.3: 42.31