HitPredict

Interactor 1: CRYAA (P02489)
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4) (Heat shock protein family B member 4) [Cleaved into: Alpha-crystallin A(1-172); Alpha-crystallin A(1-168); Alpha-crystallin A(1-162)]
Gene: CRYAA

Interactor 2: CRBB2 (P43320)
Beta-crystallin B2 (Beta-B2 crystallin) (Beta-crystallin Bp)
Gene: CRYBB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	11700327, 12601044
Identification Methods	two hybrid, affinity chromatography technology, coimmunoprecipitation, experimental interaction detection
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002088 - lens development in camera-type eye GO:0005198 - structural molecule activity GO:0005212 - structural constituent of eye lens GO:0007601 - visual perception
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 173 Hs			1 205
+	Hs
		358985 CRYAB_HUMAN (1-172): 1.92e-55: 174: 51.71		CRBB2_HUMAN (1-205): 1.16e-108: 311: 100.00
+	Hs
		388287 HSPB1_HUMAN (7-170): 4.17e-51: 164: 37.36		CRBB2_HUMAN (1-205): 1.16e-108: 311: 100.00
+	Hs
		358701 CRYAA_HUMAN (1-173): 1.42e-67: 204: 100.00		CRBA1_HUMAN (10-192): 1.9e-79: 237: 45.36
+	Hs
		358733 CRYAA_HUMAN (1-173): 1.42e-67: 204: 100.00		CRBA4_HUMAN (6-192): 4.81e-75: 225: 39.59
+	Hs
		358953 CRYAB_HUMAN (1-172): 1.92e-55: 174: 51.71		CRBA1_HUMAN (10-192): 1.9e-79: 237: 45.36
+	Hs
		358702 CRYAA_HUMAN (1-173): 1.42e-67: 204: 100.00		CRGC_HUMAN (12-100): 1.5e-17: 78.1: 28.89
+	Hs
		358714 CRYAA_HUMAN (1-173): 1.42e-67: 204: 100.00		CRBB3_HUMAN (104-201): 2.51e-16: 75.7: 33.66
+	Hs
		358703 CRYAA_HUMAN (1-173): 1.42e-67: 204: 100.00		CRGD_HUMAN (108-197): 5.5e-16: 74.2: 37.78
+	Hs
		358955 CRYAB_HUMAN (1-172): 1.92e-55: 174: 51.71		CRGC_HUMAN (12-100): 1.5e-17: 78.1: 28.89
+	Hs
		358971 CRYAB_HUMAN (1-172): 1.92e-55: 174: 51.71		CRYGS_HUMAN (12-100): 2.91e-17: 77.7: 31.11
+	Hs
		358956 CRYAB_HUMAN (1-172): 1.92e-55: 174: 51.71		CRGD_HUMAN (108-197): 5.5e-16: 74.2: 37.78
+	Hs
		388156 HSPB1_HUMAN (7-170): 4.17e-51: 164: 37.36		CRGC_HUMAN (12-100): 1.5e-17: 78.1: 28.89
+	Hs
		426907 HSPB2_HUMAN (19-159): 1.06e-39: 134: 39.44		CRGC_HUMAN (12-100): 1.5e-17: 78.1: 28.89