HitPredict

Interactor 1: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Interactor 2: SEH1 (Q96EE3)
Nucleoporin SEH1 (GATOR2 complex protein SEH1) (Nup107-160 subcomplex subunit SEH1) (SEC13-like protein)
Gene: SEH1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005198 - structural molecule activity GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 360
+	Hs
		358860 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		SEH1_HUMAN (1-360): 1.71e-77: 243: 100.00
+	Dm
		359260 HSP27_DROME (16-173): 3.16e-36: 126: 30.68		LIS1_DROME (2-253): 1.69e-49: 172: 15.56
+	Hs
		282801 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		CIAO1_HUMAN (57-321): 2.68e-22: 98: 20.71
+	Dm
		359159 HSP23_DROME (14-174): 7.01e-43: 142: 27.75		NLE_DROME (3-142): 9.24e-30: 121: 20.71
+	Hs
		358724 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		LIS1_HUMAN (272-360): 7.69e-17: 83: 16.85
+	Hs
		388341 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		SEC13_HUMAN (216-346): 5.58e-17: 82.6: 18.80
+	Hs
		283058 HSPB8_HUMAN (1-150): 8.92e-40: 135: 33.74		CIAO1_HUMAN (57-321): 2.68e-22: 98: 20.71
+	Hs
		152915 HSPB8_HUMAN (1-150): 8.92e-40: 135: 33.74		APAF_HUMAN (78-318): 4.09e-09: 60.2: 13.89