HitPredict

Interactor 1: CRYAB (P02511)
Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Heat shock protein family B member 5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component)
Gene: CRYAB

Interactor 2: HSPB8 (Q9UJY1)
Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Heat shock protein family B member 8) (Protein kinase H11) (Small stress protein-like protein HSP22)
Gene: HSPB8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	16225851
Identification Methods	two hybrid, fluorescent resonance energy transfer
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Crystallin~HSP20, HSP20~HSP20
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 175 Hs			1 196
+	Hs
		358950 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Rn
		621311 CRYAB_RAT (1-175): 3.48e-66: 201: 97.14		HSPB1_RAT (1-179): 4.16e-61: 190: 36.41
+	Hs
		388788 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		HSPB8_HUMAN (1-196): 7.92e-71: 214: 100.00
+	Hs
		1378434 V9HW27_HUMAN (1-175): 1.86e-66: 202: 100.00		V9HW27_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358943 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRYAB_HUMAN (6-187): 3.08e-53: 169: 31.69
+	Hs
		358697 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		CRYAA_HUMAN (6-187): 8.59e-53: 168: 23.53
+	Hs
		358941 V9HW27_HUMAN (1-175): 1.86e-66: 202: 100.00		CRYAA_HUMAN (6-187): 8.59e-53: 168: 23.53
+	Bt
		358695 CRYAB_BOVIN (1-175): 9.15e-67: 203: 97.71		CRYAA_BOVIN (6-190): 1.34e-51: 165: 24.32
+	Hs
		358699 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Hs
		388144 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		HSPB1_HUMAN (1-179): 9.77e-63: 194: 36.67
+	Hs
		147843 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		HSPB6_HUMAN (5-166): 4.57e-44: 146: 31.10
+	Hs
		359021 CRYAB_HUMAN (1-175): 1.86e-66: 202: 100.00		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88
+	Hs
		358696 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		CRYAA_HUMAN (6-187): 8.59e-53: 168: 23.53
+	Hs
		147844 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		HSPB6_HUMAN (5-166): 4.57e-44: 146: 31.10
+	Hs
		358767 CRYAA_HUMAN (1-172): 9.2e-55: 172: 51.98		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88
+	Hs
		388468 HSPB1_HUMAN (7-174): 3.05e-52: 167: 41.08		HSPB2_HUMAN (1-170): 5.01e-42: 141: 25.88