HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	25948554, 20000738, 23658700
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0035861 - site of double-strand break GO:0090398 - cellular senescence
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 143
+	Hs
		360118 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97
+	Hs
		359562 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70
+	Hs
		260700 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69
+	Hs
		595376 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19
+	Hs
		595247 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70
+	Hs
		260752 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69
+	Hs
		391510 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70