HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: H15 (P16401)
Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)
Gene: H1-5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	25948554, 30021884
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0007517 - muscle organ development
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 226
+	Hs
		359628 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Hs
		359864 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Mm
		794613 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		H14_MOUSE (1-206): 2.81e-20: 87.1: 63.77
+	Hs
		559324 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		H13_HUMAN (1-184): 1.62e-22: 93.3: 68.48
+	Hs
		559549 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17