HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.60	0.408

Property	Details
Experiments	12112001
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 672
+	Hs
		566280 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		KPCA_HUMAN (1-672): 0: 794: 100.00
+	Hs
		408554 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		KPCB_HUMAN (1-664): 0: 749: 78.89
+	Mm
		554876 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		KPCE_MOUSE (8-664): 0: 637: 44.76
+	Hs
		397132 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		KPCG_HUMAN (1-670): 0: 706: 68.94
+	Mm
		554861 VIME_MOUSE (27-394): 8.69e-32: 130: 29.35		KPCE_MOUSE (8-664): 0: 637: 44.76
+	Mm
		554866 DESM_MOUSE (27-389): 1.16e-30: 127: 29.48		KPCE_MOUSE (8-664): 0: 637: 44.76
+	Mm
		682101 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		AKT1_MOUSE (243-660): 1.45e-155: 459: 37.36
+	Hs
		1055200 K1H2_HUMAN (30-387): 6.02e-43: 162: 23.18		AKT3_HUMAN (283-660): 6.86e-156: 460: 40.46
+	Hs
		681844 K1H2_HUMAN (30-387): 6.02e-43: 162: 23.18		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Hs
		443354 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Hs
		443355 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		AKT2_HUMAN (242-660): 9.73e-156: 459: 39.13
+	Hs
		535333 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Mm
		589625 VIME_MOUSE (27-394): 8.69e-32: 130: 29.35		KPCZ_MOUSE (22-86): 1.13e-10: 66.6: 38.46