HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: RO52 (P19474)
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)
Gene: TRIM21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32051585
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 475
+	Hs
		531606 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		TRI58_HUMAN (1-472): 1.06e-141: 416: 43.52
+	Hs
		821686 K2C6C_HUMAN (24-407): 2.49e-116: 361: 24.03		TRIM7_HUMAN (11-450): 4.66e-121: 365: 34.03
+	Hs
		360442 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI39_HUMAN (7-469): 3.45e-150: 440: 38.32
+	Hs
		584872 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RO52_HUMAN (1-475): 3.26e-173: 497: 100.00
+	Hs
		360383 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRIM6_HUMAN (1-466): 1.7e-130: 388: 43.93
+	Hs
		443320 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		RO52_HUMAN (1-475): 3.26e-173: 497: 100.00
+	Hs
		62675 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI64_HUMAN (1-449): 3.78e-119: 358: 34.51
+	Hs
		360110 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI69_HUMAN (1-466): 3.44e-116: 352: 28.90
+	Hs
		536792 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17
+	Hs
		318774 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17
+	Hs
		443583 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TRI68_HUMAN (1-465): 4.52e-148: 433: 42.62
+	Hs
		380469 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		TRI26_HUMAN (1-354): 6.86e-55: 193: 34.73
+	Hs
		535315 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		TRI27_HUMAN (1-466): 2.88e-141: 416: 37.17
+	Hs
		535455 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		TRI69_HUMAN (1-466): 3.44e-116: 352: 28.90
+	Hs
		443767 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TRI62_HUMAN (9-467): 3.47e-112: 341: 28.84
+	Hs
		359894 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI26_HUMAN (1-354): 6.86e-55: 193: 34.73
+	Hs
		443785 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		TRI15_HUMAN (1-453): 6.84e-105: 322: 28.30
+	Hs
		318841 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		TRIMM_HUMAN (87-468): 1.31e-62: 211: 35.60