HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm GO:0071456 - cellular response to hypoxia
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 906
+	Hs
		531534 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610295 K2C6C_HUMAN (24-407): 2.49e-116: 361: 24.03		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		359466 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		380445 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610433 K2C79_HUMAN (23-398): 7.55e-42: 161: 21.90		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		443330 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610513 KRT84_HUMAN (233-645): 2.05e-11: 69.1: 13.60		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		359942 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		MDC1_HUMAN (450-878): 1.89e-11: 70.3: 9.33
+	Hs
		975714 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Hs
		595363 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Hs
		203200 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22