HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	26468281, 34316702
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 326
+	Hs
		717734 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		359706 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36
+	Hs
		318779 K2C75_HUMAN (23-390): 1.2e-45: 172: 23.85		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717925 K2C79_HUMAN (23-398): 7.55e-42: 161: 21.90		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717890 K2C71_HUMAN (23-390): 2.92e-41: 159: 21.68		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		380469 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		TRI26_HUMAN (5-210): 1e-49: 175: 16.59
+	Hs
		595115 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		PCGF2_HUMAN (1-320): 1.04e-117: 344: 61.36
+	Hs
		282510 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		282457 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		282465 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		359651 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RO52_HUMAN (5-198): 5.75e-52: 180: 18.78
+	Hs
		359894 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI26_HUMAN (5-210): 1e-49: 175: 16.59
+	Hs
		360383 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRIM6_HUMAN (5-189): 2.83e-49: 173: 16.67
+	Hs
		360442 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		TRI39_HUMAN (9-198): 1.36e-45: 163: 16.50
+	Hs
		584872 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RO52_HUMAN (5-198): 5.75e-52: 180: 18.78
+	Hs
		282458 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		975721 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		443320 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		RO52_HUMAN (5-198): 5.75e-52: 180: 18.78
+	Hs
		443747 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		443720 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		CHFR_HUMAN (8-168): 2.7e-31: 125: 19.14