HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: SRBP1 (P36956)
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]
Gene: SREBF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	19727227, 11929849, 21993218
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, isothermal titration calorimetry
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031647 - regulation of protein stability
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 1147
+	Hs
		595120 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		SRBP1_HUMAN (1-1147): 0: 910: 100.00
+	Mm
		539734 LMNB1_MOUSE (6-580): 8.76e-53: 193: 54.17		TFE3_MOUSE (134-438): 8.24e-28: 121: 19.30
+	Hs
		203200 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		SYNJ1_HUMAN (1-548): 2.99e-28: 125: 13.93
+	Mm
		589634 VIME_MOUSE (27-394): 8.69e-32: 130: 29.35		TFE3_MOUSE (134-438): 8.24e-28: 121: 19.30
+	Hs
		443586 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		ADNP2_HUMAN (2-333): 1.84e-10: 67.7: 13.73