HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29568061
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0031965 - nuclear membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 529
+	Hs
		134820 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		131360 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		238622 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37
+	Hs
		168609 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		IMA6_HUMAN (1-528): 9.99e-138: 410: 45.02
+	Hs
		359784 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Hs
		595158 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Dr
		71547 B3DKC5_DANRE (9-597): 8e-53: 194: 65.08		Q7ZVY9_DANRE (4-529): 5.3e-150: 441: 50.10
+	Hs
		238630 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37
+	Hs
		168617 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		IMA6_HUMAN (1-528): 9.99e-138: 410: 45.02
+	Ce
		1091055 LMN1_CAEEL (1-539): 1.07e-53: 195: 29.49		IMA3_CAEEL (9-529): 1.3e-130: 391: 44.25
+	Hs
		595159 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		IMA5_HUMAN (4-528): 7.39e-133: 398: 44.47
+	Dm
		445897 LAM0_DROME (13-582): 4.03e-44: 169: 34.59		IMA_DROME (6-529): 2.4e-121: 368: 48.30