HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	34825085, 15161933, 20618440
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031647 - regulation of protein stability
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 245
+	Hs
		380460 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		359676 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		595184 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		595099 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Mm
		821702 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		1433G_MOUSE (1-240): 2.37e-108: 314: 74.59
+	Mm
		250868 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		1433S_MOUSE (1-232): 7.92e-104: 302: 73.08
+	Hs
		443452 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		443445 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Mm
		372933 GFAP_MOUSE (27-427): 7.43e-30: 124: 28.68		1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59
+	Hs
		443346 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		569067 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		443356 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		569050 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Rn
		677657 VIME_RAT (27-389): 1.81e-31: 130: 28.93		1433B_RAT (1-242): 2e-128: 364: 86.78
+	Hs
		904437 KRT85_HUMAN (25-387): 4.71e-48: 178: 24.93		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		905163 KRT82_HUMAN (23-387): 1.44e-44: 168: 23.84		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		904944 KRT35_HUMAN (30-387): 1.7e-41: 158: 24.58		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		443441 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		443469 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		443357 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97