Interactor 1: DYR (P00374)
Dihydrofolate reductase (EC 1.5.1.3)
Gene: DHFR
Interactor 2: DYR2 (Q86XF0)
Dihydrofolate reductase 2, mitochondrial (Dihydrofolate reductase, mitochondrial) (EC 1.5.1.3) (Dihydrofolate reductase-like protein 1)
Gene: DHFR2
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.57 | 1.00 | 0.759 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 33961781, unassigned3799 |
| Identification Methods | affinity chromatography technology, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DHFR_1~DHFR_1 |
| Common GO terms | GO:0003729 - mRNA binding GO:0004146 - dihydrofolate reductase activity GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0006730 - one-carbon metabolic process and 5 others more... |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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| + | Ca |   |
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| + | Tm | |
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
