HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.625

Property	Details
Experiments	19596686, 16248985
Identification Methods	enzymatic study, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 158
+	Hs
		531541 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		UBE2A_HUMAN (1-154): 3.37e-67: 202: 41.56
+	Hs
		380451 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		UBE2A_HUMAN (1-154): 3.37e-67: 202: 41.56
+	Mm
		821704 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		UBC9_MOUSE (1-158): 1.43e-70: 211: 100.00
+	Hs
		595282 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		Q7KZS0_HUMAN (1-137): 2.27e-71: 214: 100.00
+	Hs
		595185 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		535443 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		Q7KZS0_HUMAN (1-137): 2.27e-71: 214: 100.00
+	Hs
		569095 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		Q7KZS0_HUMAN (1-137): 2.27e-71: 214: 100.00
+	Hs
		569068 DESM_HUMAN (27-389): 6.1e-28: 119: 30.03		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00