HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031507 - heterochromatin formation
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 746
+	Hs
		531579 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		821664 K2C6C_HUMAN (24-407): 2.49e-116: 361: 24.03		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		359498 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		380481 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		975661 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		595245 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		539735 LMNB1_MOUSE (6-580): 8.76e-53: 193: 54.17		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Mm
		1149762 K2C73_MOUSE (23-390): 2.25e-47: 177: 24.39		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Hs
		443538 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		535404 GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		422188 NFL_HUMAN (28-433): 1.96e-26: 115: 27.07		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Mm
		589636 VIME_MOUSE (27-394): 8.69e-32: 130: 29.35		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Hs
		213953 KRT86_HUMAN (250-556): 7.5e-10: 63.7: 12.93		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		331683 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		360295 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		360377 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		595392 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42