HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	23075850
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0008104 - protein localization GO:0031647 - regulation of protein stability
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 664 Hs			1 2527
+	Hs
		531584 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		3119 A0A0S2Z428_HUMAN (23-407): 5.26e-116: 360: 23.71		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		380486 K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		975674 LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130283 K2C73_HUMAN (23-390): 1.74e-50: 185: 23.85		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		595256 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130818 V9HWE1_HUMAN (27-389): 3.94e-31: 129: 28.93		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		443567 VIME_HUMAN (27-389): 3.94e-31: 129: 28.93		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		422196 NFL_HUMAN (28-433): 1.96e-26: 115: 27.07		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		72923 B4DN72_HUMAN (250-556): 7.05e-10: 63.7: 12.93		LRRK2_HUMAN (1-2527): 0: 3008: 99.72