HitPredict

Interactor 1: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Interactor 2: STAC2 (Q6ZMT1)
SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2)
Gene: STAC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	24623722
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 664 Hs			1 411
+	Hs
		359448 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		RAF1_HUMAN (8-363): 1.17e-38: 148: 12.57
+	Hs
		488553 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		ARAF_HUMAN (4-363): 1.78e-31: 128: 12.14
+	Hs
		360322 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		STAC_HUMAN (14-411): 1.31e-58: 198: 41.75
+	Hs
		280786 KRT36_HUMAN (31-457): 9.65e-119: 364: 23.83		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49
+	Hs
		531551 K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49
+	Hs
		359480 K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49
+	Hs
		359636 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		KPCA_HUMAN (80-376): 5.52e-30: 124: 13.44
+	Mm
		554876 LMNA_MOUSE (1-664): 1.23e-70: 243: 94.90		KPCE_MOUSE (37-386): 1.76e-35: 140: 14.40
+	Hs
		359835 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49
+	Hs
		595217 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		SPTN1_HUMAN (193-389): 2.19e-41: 158: 18.93
+	Hs
		373669 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		RAF1_HUMAN (8-363): 1.17e-38: 148: 12.57
+	Hs
		360200 LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00		SH3R2_HUMAN (221-362): 3.39e-11: 67.2: 13.89
+	Hs
		566280 LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37		KPCA_HUMAN (80-376): 5.52e-30: 124: 13.44
+	Hs
		374629 KRT35_HUMAN (30-387): 1.7e-41: 158: 24.58		RAF1_HUMAN (8-363): 1.17e-38: 148: 12.57
+	Mm
		554861 VIME_MOUSE (27-394): 8.69e-32: 130: 29.35		KPCE_MOUSE (37-386): 1.76e-35: 140: 14.40
+	Hs
		924679 K2C73_HUMAN (23-390): 1.74e-50: 185: 23.85		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49
+	Hs
		924470 KRT85_HUMAN (25-387): 4.71e-48: 178: 24.93		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49
+	Hs
		924895 KRT82_HUMAN (23-387): 1.44e-44: 168: 23.84		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49
+	Hs
		924575 K1H2_HUMAN (30-387): 6.02e-43: 162: 23.18		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49
+	Hs
		924741 KRT35_HUMAN (30-387): 1.7e-41: 158: 24.58		GRB2_HUMAN (230-352): 2.23e-17: 82.2: 26.49